Alternative medicine is becoming popular worldwide and this is clearly evident from the rapidly escalating sales figures. The time tested and clinically proven herbal medicines like Aloe vera, St John’s wort, Gingo biloba, Garlic, Ephedra etc., make up most of the world’s market as for as alternative medicine is concerned. Advances in western medicine have dramatically increased health conditions and life expectancy of people. In spite of the latest developments in allopathic system of medicine people still seek alternative and complimentary system. The use of herbal medicine to treat a wide range of conditions is rising rapidly, leading to increased intake of phytochemicals. Recent studies reveal potential fatal interactions between herbal medicines and drugs. Herbal medicine is amongst the 16 alternative systems of medicine, which is used to treat existing illness and also for preventive and health conditions. Herbs like Aloe vera, St John’s wort, Ginkgo biloba, Feverfew, Ginger and Kava make most of the market. The increasing popularity of alternative therapies, including herbal remedies is a new challenge for health care providers because the evidence on safety for herbal remedies incomplete, complex and confusing. The herbal medicines are certainly associated with risks and benefits. Interaction between herbal medicines and drugs are based on the same pharmacokinetic and pharmacodynamic principles as like drug-drug interactions. Now present condition patients taking both ayurvedic and allopathic treatment remain aware of potential herb-drug interaction and avoid taking medications .which might prove hazardous to their already deteriorating health. This article provides brief idea about pharmacist can change the present scenario and utilize their knowledge in providing healthy information about herb-drug interaction.