Background: Chronic periodontitis, correlated with Dantamoolagata Roga (specifically Sheetada) in Ayurveda, is a primary driver of tooth loss characterized by gingival inflammation and clinical attachment loss. While chemical mouthwashes like Chlorhexidine are the established gold standard, their long-term application is frequently limited by adverse effects such as tooth staining and dysgeusia . Objective: To clinically evaluate the efficacy of Gandusha (oil pulling) using Til Taila (Sesame oil) as an adjunct to mechanical debridement in the management of generalized chronic periodontitis. Methods: This clinical investigation utilized a single-case experimental design. A patient diagnosed with generalized chronic periodontitis underwent Scaling and Root Planing (SRP) as a primary intervention. This was supplemented by a 30-day regimen of daily Gandusha with lukewarm Til Taila for 3–5 minutes. Clinical parameters, including the Plaque Index (PI), Gingival Index (GI), and Bleeding on Probing (BOP), were assessed at baseline and post-intervention. Results: Post-treatment analysis revealed significant clinical improvements. There were marked reductions in PI, GI, and BOP scores, indicating a substantial decrease in microbial biofilm accumulation and gingival inflammation. The emulsification and saponification processes of the sesame oil likely contributed to these outcomes by reducing bacterial adhesion and exerting antioxidant effects via lignans such as sesamin and sesamol . Conclusion: Til Taila Gandusha is an effective, safe, and cost-efficient Ayurvedic intervention. When used as an adjunct to mechanical debridement, it enhances periodontal healing and provides a viable, side-effect-free alternative for long-term oral hygiene maintenance.