This data is used to reproduce the results of Rice leaf pathogen infection alters the spectral–biochemical relationships revealed by radiative transfer model inversion This folder contains MESMA analysis output images derived from hyperspectral images collected for varieties VD, VE, and VF. Each image, stored as a `.raw` file with an accompanying `.hdr` file, consists of seven bands, including the fractional abundance of different endmembers (healthy and infected) and model uncertainty parameters. Each image is also accompanied by two `.csv` files containing the model parameters. This folder also contains the spectral library (821_VD_7) we selected for unmixing. For the MESPECT algorithm introduced in this paper, users are recommended to align the MESMA results with the corresponding HSI images, select pixels with F_infected values greater than 0, and record the endmember combinations used in the unmixing analysis. Then, PROCWT should be performed on each healthy endmember in the spectral library to extract biochemical parameters. For each pixel in an image, its biochemical parameters can then be derived by multiplying F_healthy by BIO_healthy, where BIO_healthy represents the biochemical parameters of the corresponding healthy endmember.