The use of plant compounds to treat infection is an age old practice in a large part of the world, especially in developing countries, where there is depend.ence on traditional medicine for a variety of diseases. Euphorbia sp. are used in traditional medicines. Hypotensive and tonic properties are also reported in E. hirta. The aqueous extract exhibits anxiolytic, analgesic, antipyretic, and anti-inflammatory activities. Methanolic extract of leaves have antifungal and antibacterial activities. In this work different concentration shows as 100, 75, 50, 25% and under controlled gave inhibition zone as 9.33, 6.02, 4.48, 3.66 but controlled patriplaite full of microorganism