Single-nucleus RNA sequencing of miBrains, a human brain tissue model

Authors: Mesentier-Louro, Louise A.; Goldman, Camille; Buonfiglioli, Alice; Kyriakis, Dimitrios; Fullard, John F.; Hennigan, Evelyn; Lee, Donghoon; +2 Authors

doi: 10.5281/zenodo.21510592 , 10.5281/zenodo.21510593

Single-nucleus RNA sequencing of miBrains, a human brain tissue model

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Abstract

This dataset contains snRNA-seq data generated from human induced pluripotent stem cell-derived 3D brain tissue. Specifically, this is a multicellular integrated human brain tissue (miBrain) containing multiple brain cell types. The dataset includes three experimental conditions: control miBrains, miBrains with overexpression and mutation of the SNCA gene (A53T) and the APOE3/3 genotype, and miBrains with SNCA-A53T and APOE4/4 genotype. The SNCA manipulation is present only in the neurons, whereas the APOE genotype manipulation is identical in all cell types within the same sample. Control miBrains express endogenous SNCA and harbor APOE3/3. All miBrains are isogenic.

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