This document is a report on a portfolio of case/feasibility studies on the ISBE concept. The main objectives of this report are as following: To monitor, assess and where relevant, identify and foster the implementation of case studies, testing whether ISBE methodologies work Compilation and translation of success stories in lay language in the field of the life sciences (i.e. from gene to ecosystems, including, e.g. the Virtual Patient, production of new pharmaceuticals, novel animal and plant breeding systems, industrial production of microbe and algae-based chemicals, etc.). Prepare the science case arguments and evidence to elucidate governments, policy-makers, funders and industry