This dataset contains the raw experimental data supporting the article "Moss-derived recombinant Factor H, CPV-104, effectively antagonizes alternative pathway C3/C5 convertases stabilization by NeFs from patients with primary C3 glomerulopathy", published in Frontiers in Immunology, 2026. The dataset includes the following files: Western blot raw data (Figure 1, Supplementary Figure S1, and Supplementary Table S1). Western blot raw data (Figure 2, Supplementary Figure S2, and Supplementary Table S2). ELISA C3a raw data (Figures 3A, 4A, and 4B). ELISA C3a raw data (sCR1 experiments). ELISA Ba raw data (Figures 3B, 4C, and 4D). The files contain the original experimental data underlying the figures and supplementary material reported in the associated publication.