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Preprint . 2026
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AION — Algebraic Interval Ontology for Clinical Networks (FM-3)

Authors: Matten, Friedhelm;

AION — Algebraic Interval Ontology for Clinical Networks (FM-3)

Abstract

AION (Algebraic Interval Ontology for Clinical Networks) is a fully general formal mathematical model of clinical information systems, containing FM-1 as a special case and extending it in all dimensions. Extensions include: a type system with type hierarchy and schema inheritance for arbitrary clinical event types; a universal event model covering examinations, therapies, diagnoses, and observations as typed, attributed time-interval events; a complete temporal relation algebra (all 13 Allen relations); a hierarchical process model with directed acyclic graphs (DAGs); an extended formal query language with temporal quantifiers, cohort combination and multi-patient relations; a causal model with do-operator and counterfactual queries; FHIR mapping as a structural homomorphism; a formal AI layer model; and federation with Differential Privacy guarantees. The reference implementation is available as the Python package aion-clinical on PyPI. NOT a medical device (EU MDR 2017/745 / MPDG). Version 1.2 corrects four findings from an external mathematical review (errata E-4–E-7): the sign in P(precedes), the distributional assumption of the probabilistic Allen relations, the second unit indicator of the contact duration, and the notation of counterfactual queries. In addition: a formal m-nearest-neighbour definition of the matching operator, heuristic labelling of the Shapley back-propagation, and an NP-hardness note on sufficient explanations. Lizenz: Dieses Dokument steht unter AGPL-3.0-only. Alternativ ist eine kommerzielle Lizenzierung durch die ISCaD GmbH auf Anfrage über licensing@iscad-it.de verfügbar. Version 1.3: Lizenz-Restfundstellen (nun durchgängig AGPL-3.0-only) und Software-URL (fm2-project/cairn → iscad/aion) korrigiert, Erratum E-8. Keine inhaltliche Änderung.

Dual-licenced: AGPL-3.0-only OR Commercial (ISCaD GmbH). Commercial licence: licensing@iscad-it.de. NOT a medical device (EU MDR 2017/745).

Keywords

AION, formal methods, federated learning, FM-3, DAG, FHIR, clinical knowledge graph, temporal algebra, HL7, Algebraic Interval Ontology, Allen algebra, differential privacy, clinical informatics, causal inference, health informatics

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
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