This data set corresponds to the data published in: Krzyzaniak O, Steiner S, Nilsson FAM, Dietrich M, Kämpfen L, Johansen P, Jirkof P, Meyer U. Carprofen and buprenorphine delivery using micropipette-guided drug administration (MDA) in mice. Neuropsychopharmacology. 2026 May 20. doi: 10.1038/s41386-026-02445-8. Epub ahead of print. PMID: 42162265. In this study, we evaluated whether the micropipette-guided drug administration (MDA) method, which promotes voluntary consumption using a sweetened condensed milk vehicle, achieves therapeutically relevant plasma and brain concentrations of two widely used analgesics, carprofen and buprenorphine, in male and female C57BL/6 N and BALB/c mice.