This study assessed the knowledge, attitude, and practices (KAP) regarding infection control, sanitation, and safety among dental health practitioners in North Central Nigeria. A cross-sectional descriptive design was used, involving 416 dental health practitioners from eight dental clinics. Results showed inadequate knowledge, attitude, and practices regarding infection control, with only 33.2% recognizing the importance of hand hygiene, 24.0% acknowledging the essential role of PPE, and 50.0% believing infection control is important. Practices like hand hygiene (28.9%) and PPE use (25.5%) were inadequate. The study highlights the need for targeted interventions to improve infection control practices and patient safety in dental clinics.