This monograph provides a concise overview of the emerging role of trimethylamine N-oxide (TMAO), a gut microbiota-derived metabolite, in the pathogenesis of atherosclerosis. It reviews the molecular mechanisms linking TMAO with endothelial dysfunction, vascular inflammation, and atherogenesis, together with current and emerging TMAO-targeted therapeutic strategies. Intended for medical students, clinicians, researchers, and healthcare professionals, the booklet summarizes current evidence in cardiovascular and translational medicine. Author website: https://drhakimemedivault.com Google Scholar Profile: https://scholar.google.com/citations?user=VnL3NuoAAAAJ&hl=en Google Books Catalogue: https://books.google.com/books?q=inauthor:%22Hakim+Saboowala%22 (Open in New Window)