Aim: To analyze the neural damage in cases with first time CABG comparing the outcomes in therapies using the heart-lung machine and those avoiding the use. Method: We took 12 beginners who were to undergo a CABG at Allied Hospital, Faisalabad from February to September 2017 and randomly subjected them to off-pump and on-pump therapy. We computed the difference in the NIH Stroke Scale results after every 30 days. Outcome: The category of patients with on-pump therapy scored higher on NIHSS than that with off-pump surgery. After thirty days of the operation, the occurrence of Transient Ischemic Attack came out to 15.3 % as reported by on-pump patients and 5 percent reported by the off-pump patients with a P value equal to 0.05. On-pump patients showed a greater occurrence of CVA than the off-pump patients (3.4% & 0% respectively) with a P value of 0.05. Conclusion: A greater number of neural issues follow an on-pump CABG therapy than an off-pump one. Keywords: CABG, neural issues, Transient ischemic attack.