Enterprise multi-agent architectures suffer from brittle routing, unquantified uncertainty, and vulnerability to Byzantine failures. We present Super-Gems v3.0, a topology treating specialized agents as structurally indexed nodes within a content-addressable lattice. This specification introduces epistemic uncertainty-aware routing—a routing function that jointly optimizes embedding similarity, capability coverage, permission compatibility, and confidence calibration. We formalize the routing matrix with provenance tracking, prove complexity bounds under hierarchical vector indexing with uncertainty-aware candidate expansion, specify Byzantine-fault-tolerant health monitoring with cryptographic non-repudiation, and provide reproducible evaluation benchmarks. The reference implementation demonstrates sub-millisecond routing at 100,000-node scale with automatic failover, state checkpointing via the Model Context Protocol (MCP), and differentially private embedding aggregation for cross-organizational federation.