EOSC-ENTRUST aims to create a European network of Trusted Research Environments (TREs) for sensitive data and drive European interoperability between TREs by development of a common blueprint for federated data access and analysis – the EOSC-ENTRUST Blueprint & Interoperability Framework (Blueprint, for short). This document is the third version of the EOSC-ENTRUST Blueprint Roadmap (Roadmap, for short), presenting a final overview of the steps needed to arrive at the Blueprint that meets requirements from the project use cases, referred to as Drivers, and is viable for TRE providers (referred to as Providers).