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Preprint . 2026
License: CC BY
Data sources: ZENODO
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
ZENODO
Preprint . 2026
License: CC BY
Data sources: ZENODO
ZENODO
Preprint . 2026
License: CC BY
Data sources: Datacite
ZENODO
Preprint . 2026
License: CC BY
Data sources: Datacite
ZENODO
Preprint . 2026
License: CC BY
Data sources: Datacite
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Pattern Fidelity Index and Regenerative Coherence

Authors: Reece O'Sullivan;

Pattern Fidelity Index and Regenerative Coherence

Abstract

Regeneration is not simply growth after injury. It is growth constrained by retained pattern information. This manuscript develops Pattern Fidelity as a measurable companion principle to Cooperative Coherence Theory. Pattern Fidelity is defined as the capacity of local cellular populations to perceive, maintain, and restore organism-level target states following disruption. The paper integrates developmental biology, regeneration research, bioelectric patterning, Wnt-Hox signaling, ion-channel control, extracellular matrix and laminin context, gap junction coupling, and cancer ecology. It adds a Pattern Fidelity Index (PFI), a hierarchy of component fidelities, a worked numerical example, and explicit falsification criteria. Human embryonic tail regression, lizard and salamander tail regeneration, planarian polarity rewriting, and Xenopus tail regeneration are used as examples showing that the same toolkits can produce construction, pruning, regeneration, scarring, malformed repair, cancer, or irreversible loss of pattern coherence depending on timing, context, coupling, and target-state fidelity. The central claim is that growth becomes regenerative only when it remains coupled to structural memory, bioelectric coordination, positional identity, repair capacity, and higher-order organismal coherence.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green
Related to Research communities
Cancer Research