The aim of the study is to find out the safety issues of the nurses of selected hospitals in Roxas, Isabela to improve the administrative support from the institution in terms of their needs and issues on safety in the workplace. The study was conducted among 79 staff nurses in selected hospital, using the research-made questionnaire based on the related literature with the cronbach’s alpha of 0.919. The statistical tools to analyzed the data are frequency, percentage, mean, Kruskall-Wallis and Math Whitney U Test. The result reveals majority of nurses are aged 22-26 (54.4%), mainly female (75.9%), and single (64.6%), with most holding a bachelor's degree in nursing (98.7%) and having less than three years of experience (60.8%). Safety policies are largely viewed as a "Most Common Issue" with a category mean of 3.40. Concerns about safety policies are prominent, especially regarding clarity and response channels. Issues include management of work hazards and reporting. Protective equipment and facility safety also score highly. There are no significant differences in safety issues based on the demographic profile, suggesting uniformity in safety perceptions among nurses in Roxas, Isabela. In Conclusion, study reveals a young, female, single nursing workforce with limited experience, primarily in medical-surgical units at hospital B, facing significant safety issues, particularly regarding PPE, with consistent challenges across demographic groups, necessitating improved safety programs. Recommendations include conducting safety training for nurses, ensuring organizational support and compliance with safety regulations, and pursuing further studies on healthcare workplace safety and injury exposure.