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Focusing on foci: Expansion Microscopy for high-resolution characterization of repeat RNA-protein aggregates in DM

descriptionPublicationkeyboard_double_arrow_right Conference object Under curation English Publisher:Zenodo
Authors: Gaspari, Sofia; Willemse, Marieke; Hoekman, Thomas D.; van Bokhoven, Hans; Wansink, Derick G.;

doi: 10.5281/zenodo.20717534

Focusing on foci: Expansion Microscopy for high-resolution characterization of repeat RNA-protein aggregates in DM

Abstract

A key feature of myotonic dystrophy type 1 (DM1) and 2 (DM2), is the accumulation of RNA-protein aggregates, primarly in cell nuclei. However, unravelling their structure, dynamics, and function remains a challenge. To resolve RNA foci ultrastructure, we introduced Expansion Microscopy (ExM) as an innovative approach to DM research. The combination of ExM with other techniques, such as single-molecule inexpensive FISH (smiFISH), provides another approach to high-resolution visualization of MBNL-C(C)UG repeat transcript complexes in cell types relevant to DM pathology.

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