Abstract: Vaccine misinformation has emerged as a major public health challenge that threatens immunization programs worldwide. The rapid dissemination of inaccurate and misleading information through social media, online platforms, and interpersonal networks has contributed to vaccine hesitancy, declining vaccination rates, and the resurgence of vaccine-preventable diseases. Community nurses occupy a strategic position in combating vaccine misinformation due to their close engagement with individuals, families, and communities. Through health education, counseling, community mobilization, digital literacy promotion, and evidence-based communication strategies, community nurses play a pivotal role in strengthening vaccine confidence and improving immunization uptake. This review explores the nature and impact of vaccine misinformation, factors contributing to vaccine hesitancy, and evidence-based community nursing interventions designed to reduce misinformation and promote informed decision-making regarding vaccination. The article highlights the importance of culturally sensitive communication, community partnerships, digital health literacy, social media engagement, and policy support in addressing vaccine-related misconceptions. The review concludes that community nurses are essential agents in combating misinformation and fostering resilient, informed communities capable of making evidence-based vaccination decisions.