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ZENODO
Software . 2026
Data sources: ZENODO
ZENODO
Software . 2026
Data sources: Datacite
ZENODO
Software . 2026
Data sources: Datacite
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OpenKnotAI: code for RNA library design, SHAPE data processing, OpenKnot scoring, and RNA design methods

Authors: Townley, Jill; Kladwang, Wipapat; Baker, David; Blair, Hamish M.; Choe, Christian A.; El Nesr, Gina; Favor, Andrew; +20 Authors

OpenKnotAI: code for RNA library design, SHAPE data processing, OpenKnot scoring, and RNA design methods

Abstract

Code accompanying the OpenKnotAI study, “De novo design of RNA pseudoknots with deep learning” (preprint: https://doi.org/10.64898/2026.05.21.726960). This deposit bundles source-only snapshots (Git history removed) of the software used for RNA library design, SHAPE chemical-mapping data processing, OpenKnot scoring, and the RNA sequence/structure design methods evaluated in the study. Each tool is provided as an individual .zip file so it can be downloaded and browsed separately. See README.md and MANIFEST.md for upstream URLs, commit SHAs (all retrieved 2026-06-11), licenses, and the role of each tool. Every bundled tool retains its own upstream LICENSE file. Rosetta is third-party proprietary software and is linked, not redistributed (see LINKED-TOOLS-rosetta.md). Bulk experimental data (SHAPE sequencing reads, cryo-EM maps, design data) are deposited separately and cross-linked from this record.

Keywords

pseudoknot, chemical mapping, RNA, OpenKnot, cryo-EM, SHAPE, RNA design, inverse folding

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Top 10%
Average
Average