This is the fourth and most comprehensive edition of the theoretical framework introduced in the original preprint (DOI: 10.5281/zenodo.17834958). The Universal Distributed Architecture (UDA) proposes a three-dimensional quantum blockchain of Planck-scale quantum cubes governed by a novel Proof-of-Consciousness (PoC) consensus protocol. Five core equations are rigorously derived and proven: the PoC consensus operator (Kraus representation), the Absolute validator state, ledger entropy growth rate (Lindblad form), OAM entanglement threshold, and quantum-resistant hash function. The work integrates loop quantum gravity, AdS/CFT correspondence, the Sachdev-Ye-Kitaev (SYK) model, JT gravity, and holographic tensor networks (MERA, PEPS, and 5D extensions), together with five-dimensional optical memory crystals (University of Southampton) as an experimental substrate, with equations 27–34 establishing Rayleigh scattering as a physical implementation of holographic hash verification and a room-temperature experimental protocol. Version 4 introduces three structural advances. (1) A ledger isomorphism (Proposition 0): every axiom of a distributed append-only ledger — immutability, decentralized consensus, append-only ordering, bounded block capacity, and double-spend prohibition — is shown to be independently realized by an established physical principle (no-cloning/no-deleting theorems, quantum Darwinism, the second law, the Bekenstein–Bousso bound, and monogamy of entanglement), localizing UDA's novel content entirely in the validation rule. (2) An operational, laboratory-reproducible definition of the consciousness quantity, |Q| = m/m_P = ω_C·t_P, integrating Inomata's pan-psychist quantity Q = i√G·M and measurable through three independent channels: Compton-clock interferometry and gravitationally induced entanglement (BMV), a standardized measurement-induced-phase-transition (Q-MIPT) meter on quantum processors with explicit calibration and uncertainty budget, and collider bounds on event-driven non-unitarity anchored by ATLAS/CMS top-quark entanglement and neutral-kaon CPT interferometry. The channel-universality law Q_G = Q_I = Q_C is the flagship prediction exclusive to UDA. (3) A sharp mathematical distinction between the anti-Hermitian consciousness operator (magnitude of agency: write capacity per Planck tick) and the Hermitian moral operator (valence of agency: mutual-information gain per unit entropy budget), with an explicit laboratory protocol distinguishing them. The framework further develops a SYK–Consciousness correspondence with non-Hermitian topological phases, MIPT modulated by consciousness density, and non-Hermitian MERA networks exhibiting a Holographic Skin Effect that topologically protects conscious information at the holographic boundary. UDA's non-unitarity is event-driven rather than continuous, making it consistent by construction with Diósi–Penrose bounds and separable from collapse models in a single two-parameter experiment (Discriminator D1). Falsifiable predictions are organized in two tiers — five UDA-exclusive predictions (2026–2030), each with its own falsification clause, and inherited consistency tests — alongside detailed QuTiP simulations, NV-center and 5D crystal protocols, and applications in quantum computing, quantum AI, and high-energy tests at the LHC and FCC. The framework resolves the von Neumann measurement chain via dual observation and portrays the universe as a growing, error-corrected quantum ledger.