Aloe Vera is a succulent plant know for its think, gel like Aloe Vera is often mix with alcohol in homemade or commercial hand sanitizer to counteract the drying effect of alcohol aloe vera is provide moisturizing and smoothness to give the skin combining Aloe Vera maintaining hygiene while reduce the dryness from skin the alcohol Aloe Vera is plant that originally come from north Africa this gel is mostly water but also has vitamin people have been using Aloe Vera for a long time to so the burn heal small cut and irritated skin even today its still used in many skincare and health product because its gentle, natural, and skin the medical and cosmetic benefits of Aloe Vera have long been recognized .this review highlights the antimicrobial and moisturizing qualities of Aloe Vera while examining its potential as a hand sanitizer A loe Vera gel is a promising substitute for artificial hand sanitizer because it has been demonstrated to stop the growth of a variety of microorganisms such as bacteria, viruses, and fungi.