The present study focuses on the development and evaluation of a cosmeceutical for the treatment of vascular periorbital hyperpigmentation (POH) using caffeine as the active ingredient. The aim of the study was to formulate a safe, effective, and economical serum capable of improving microcirculation and reducing vascular hyperpigmentation around the periorbital area. The serum was prepared using suitable base formulations and nano emulsion techniques to enhance the effectiveness of the active ingredients. Base formulations and nano emulsions were developed and compared for their physicochemical and stability characteristics. The prepared formulation was evaluated for various parameters including viscosity, pH, colour, odour, and skin irritation by patch test method. The results indicated that the formulation was stable, smooth in texture, non-irritant, and suitable for topical application. The presence of caffeine and other ingredients contributed to improved microcirculation and showed promising potential in the treatment of vascular periorbital hyperpigmentation. Thus, the developed cosmeceutical serum can be considered a promising alternative for the management of vascular POH.