AbstractAllergic rhinitis is a common inflammatory disorder affecting the nasal mucosa andsignificantly reducing quality of life. The present study focused on the formulation andevaluation of thermosensitive nasal gel of loratadine for improved intranasal drug delivery.Thermosensitive nasal gels were prepared using Poloxamer 407 as thermoreversible polymeralong with mucoadhesive polymers such as Carbopol 934P and HPMC. The formulationswere prepared by cold method and evaluated for physicochemical parameters including pH,gelation temperature, viscosity, drug content, mucoadhesive strength, spreadability, in-vitrogelation, and drug release studies. The optimized formulation exhibited satisfactory gelationtemperature near physiological nasal temperature, good mucoadhesive properties, andsustained drug release profile over 6 hours. Stability studies confirmed that the formulationremained stable under accelerated conditions. The developed thermosensitive nasal gel ofloratadine may serve as an effective alternative to conventional dosage forms by improvingnasal residence time, bioavailability, patient compliance, and therapeutic efficacy in allergicrhinitis management.