Abstract This paper proposes a unified framework linking early embodied experience, neurological baseline development, and long-term brain health outcomes including creativity, mental health, and susceptibility to neurodegeneration. Building on the foundational framework of The Uncalibrated Self (Wijn, 2026), this paper extends the argument across the full lifespan: from the multisensory richness of outdoor play in large families, the natural developmental environment of most of human history, through the systematic suppression of that richness in contemporary childhood, to the measurable consequences at the far end of life: accelerated cognitive decline and Alzheimer’s disease. The central thesis is that the inner compass, the interoceptively calibrated, sensorially integrated self, is not merely a psychological resource but a neurological architecture. When it is well established in early life, it sustains coherent functioning across the lifespan. When it is not established, the consequences compound progressively, from creativity loss in childhood to identity fragility in adolescence to accelerated neurodegeneration in old age. Evidence from indigenous population studies, long-term meditation research, creativity decline data, and neuroimaging of lifelong embodied practitioners converges on a single conclusion: the quality of early sensory experience determines the trajectory of the entire neurological life.