We present a systematic reconciliation of all major observational anomalies and tensions with ΛCDM against the predictions of the brane-bulk sump framework. As of April 2026 the Hubble constant tension has exceeded 6σ (Di Valentino et al. 2026, Nat. Astron.), DESI DR2 shows 4.2σ evidence for dynamical dark energy, JWST has conrmed massive galaxies at z > 10, the Little Red Dot population has been revised by high-resolution spectroscopy (Nature January 2026), the cosmic dipole anomaly exceeds kinematic expectations at 5σ, and CMB large-scale anomalies persist. The framework re- solves 13 anomalies and generates 16 new predictions (Predictions 56-66 and 3 additional conrmations from DESI, LRD, and super-Chandrasekhar BH seeds). The fundamental theorem connecting baryogenesis, QCD connement, and galactic dynamics is stated, connecting all anomalies to a single causal chain. No free parameters are added.Part of the One-Octonion Brane-Bulk Framework series. Anchor DOI: 10.5281/zenodo.19120873. Community: one-octonion-brane-bulk. Author: Bharathi Dasan Jagadeesan, M.D., University of Minnesota. ORCID: 0000-0002-1143-941X.