The Gut-Selenium-Thyroid Axis: Microbiome-Dependent Selenium Biotransformation, Bacterial Deiodinase Activity, and Dysbiosis as a Third Route to SIK Axis Failure Independent of Dietary Selenium or Iodine Status
The Gut-Selenium-Thyroid Axis: Microbiome-Dependent Selenium Biotransformation, Bacterial Deiodinase Activity, and Dysbiosis as a Third Route to SIK Axis Failure Independent of Dietary Selenium or Iodine Status
This paper proposes that gut dysbiosis represents a third route to Selenoprotein Axis failure through three simultaneous mechanisms: (1) disruption of beneficial bacteria that convert dietary selenium to bioavailable selenomethionine, reducing effective selenium delivery even when dietary intake is adequate; (2) loss of bacteria with deiodinase activity that participate in enterohepatic T3/T4 recycling, reducing effective thyroid hormone activation independently of the hepatic deiodinase step; (3) increased intestinal permeability from dysbiosis allowing endotoxin to enter circulation, activating NF-kB and amplifying hepcidin elevation. A 2025 Nature npj Science of Food review confirmed that gut microbiota can metabolize and transform selenium. A 2025 Frontiers review confirmed that gut microbiome regulates thyroid hormones through its own deiodinase activity. All claims are hypothesis-level.
bile acids, Lactobacillus, enterohepatic T3 recycling, intestinal permeability, secondary bile acids, gut-thyroid axis, selenoprotein axis, gut microbiome, selenium biotransformation, dysbiosis, Akkermansia, bacterial deiodinase, Hashimoto
bile acids, Lactobacillus, enterohepatic T3 recycling, intestinal permeability, secondary bile acids, gut-thyroid axis, selenoprotein axis, gut microbiome, selenium biotransformation, dysbiosis, Akkermansia, bacterial deiodinase, Hashimoto
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).0 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!