A Proposed Selenium Deficiency Staging Framework: SELENOP-Guided Clinical Staging of Selenoprotein Reserve Depletion Across High-Metabolic End-Artery Tissues — From Subclinical to Multi-Organ Vulnerability
A Proposed Selenium Deficiency Staging Framework: SELENOP-Guided Clinical Staging of Selenoprotein Reserve Depletion Across High-Metabolic End-Artery Tissues — From Subclinical to Multi-Organ Vulnerability
This paper proposes a four-stage clinical selenium deficiency framework based on SELENOP saturation kinetics and organ-specific vulnerability hierarchy: Stage 0 (Adequate: SELENOP at saturation ≥5 mg/L); Stage 1 (Subclinical insufficiency: SELENOP 3.5-5 mg/L, pulmonary and renal GPx partially reduced); Stage 2 (Functional deficiency: SELENOP 2.0-3.5 mg/L, deiodinase T4-to-T3 conversion impaired); Stage 3 (Multi-organ deficiency: SELENOP below 2.0 mg/L, all selenoprotein systems compromised). A 2025 Berlin Aging Study II analysis (n=1,568) confirmed that low SELENOP and GPx3 are associated with accelerated biological aging measured by DNA methylation clocks. The SUSTAIN CSX trial confirmed GPx3 activity predicts 6-month survival (AUC 0.73) in cardiac surgery patients. All claims are hypothesis-level.
deiodinase, Berlin Aging Study, kidney, cardiovascular mortality, biological aging, selenoprotein hierarchy, tinnitus, selenium deficiency staging, SELENOP, GPx3, clinical staging framework, ferroptosis, lung
deiodinase, Berlin Aging Study, kidney, cardiovascular mortality, biological aging, selenoprotein hierarchy, tinnitus, selenium deficiency staging, SELENOP, GPx3, clinical staging framework, ferroptosis, lung
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).0 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!