Artificial Intelligence (AI) is creating new opportunities for skill development and entrepreneurship, especially in India. In developing countries, many chemistry students and youth lack practical laboratory skills due to high costs, safety concerns and limited resources. Traditional chemistry education often depends on expensive chemicals and infrastructure, making it less accessible. Green Chemistry offers a sustainable solution by promoting eco-friendly reactions, safer solvents and waste reduction. AI can support this by predicting chemical reactions, suggesting greener methods and enabling skill-based learning. This paper highlights how AI-based tools, virtual labs and mobile platforms can train youth in green chemistry and support entrepreneurship. The study also discusses outcomes, challenges, government initiatives, ethical concerns and future scope.