Abstract Pulse diagnosis has traditionally been regarded as a subjective palpation technique rooted in East Asian medicine. In contemporary biomedical contexts, however, it is often interpreted narrowly as an indirect assessment of cardiovascular structure or hemodynamics. Such interpretations fail to capture the integrative regulatory processes reflected in clinically perceived pulse qualities. This paper aims to reconceptualize pulse diagnosis as a functional indicator of autonomic regulation, positioning it as an individualized diagnostic interface rather than a structural or organ-specific assessment. Within the framework of Oriental Medicine Neurodynamics (OMN™), pulse characteristics are examined as functional phenotypes emerging from the integration of autonomic nervous system activity, cardiac function, fluid regulation, and central rhythm coordination. Key palpatory dimensions—including vascular wall tension, rate, volume- related qualities, pulsation strength, and rhythm—are analyzed as expressions of coordinated regulatory dynamics. Pulse diagnosis is shown to reflect real-time, individualized regulatory states that cannot be adequately captured by isolated physiological parameters or population-based reference ranges. By evaluating qualitative patterns rather than single variables, pulsediagnosis enables assessment of individual differences in regulatory balance and compensatory dynamics. Reframing pulse diagnosis as a functional phenotype of autonomic regulation provides a conceptual bridge between traditional palpation practices and contemporary systems- based approaches in integrative medicine. This framework supports individualized assessment by complementing quantitative measurements with integrated, real-time evaluation of regulatory dynamics.