Gastroparesis is a chronic, often debilitating disorder of gastric motility defined by objectively delayed gastric emptying in the absence of mechanical obstruction, with symptoms persisting for at least three months. The clinical presentation—dominated by nausea, vomiting, early satiety, postprandial fullness, bloating, and abdominal pain—correlates only modestly with the degree of emptying delay, posing a persistent diagnostic challenge. The underlying pathophysiology is multifactorial, involving dysfunction at multiple levels: autonomic (vagal and sympathetic) dysregulation, impaired antral contractility, pyloric sphincter abnormalities, loss of interstitial cells of Cajal (the gastric pacemakers), and, increasingly recognized, localized inflammatory infiltration of the myenteric plexus. The most common etiologies are idiopathic (approximately 50% of cases), followed by diabetic, postsurgical, and postinfectious causes. Diabetic gastroparesis, more frequent and severe in type 1 diabetes, is closely linked to poor glycemic control and other autonomic neuropathies, while postsurgical gastroparesis often results from iatrogenic vagal injury. The incidence has risen markedly over recent decades, paralleling increases in diabetes, obesity, and use of causative medications such as GLP-1 agonists and opioids. Diagnostic evaluation centers on gastric emptying scintigraphy, the gold standard, with the wireless motility capsule and gastric emptying breath test serving as useful alternatives. Treatment requires a holistic, interprofessional approach: dietary modification (small, low-fat, low-fiber meals) forms the foundation; pharmacotherapy is limited, with metoclopramide as the only FDA-approved prokinetic, though its use is constrained by a black box warning for tardive dyskinesia. Off-label agents including domperidone, erythromycin, and antiemetics provide symptomatic relief. For refractory cases, gastric electrical stimulation offers a surgical option, particularly in diabetic patients. Prognosis varies widely by etiology: postinfectious gastroparesis often resolves within 12 months, while diabetic and idiopathic forms tend to be chronic, with significant impacts on quality of life, nutritional status, and healthcare utilization. An interprofessional team—integrating gastroenterologists, dietitians, pharmacists, diabetes educators, and mental health professionals—is essential to optimize outcomes in this challenging patient population.