This article analyzes the technological importance of the degreasing stage in leather manufacturing, as well as its effect on leather quality and subsequent processing operations. Raw hides contain natural fats, protein residues, impurities, and other organic substances that may negatively affect the uniform tanning, dyeing, and finishing of leather. Therefore, the degreasing process is an important stage in reducing excess fats between leather fibers, ensuring the uniform penetration of chemical reagents into the leather structure, and improving the physical and mechanical properties of finished leather. The article discusses degreasing methods, the reagents used, factors influencing process efficiency, and environmental aspects.