v1.0.0 — Initial Public Release We are excited to announce the initial release of the software and source codes associated with our study: "Plasticity of Human Microglia and Brain Perivascular Macrophages in Aging and Alzheimer's Disease". This repository contains the complete computational pipelines, analysis scripts, and reproducible workflows utilized to investigate the transcriptomic profiles of human myeloid single-cell cohorts. Key Features & Contents Single-Cell/Single-Nucleus Genomics Pipelines: Scripts optimized for quality control, filtering, and processing of single-cell datasets. Differential Expression & Downstream Analysis: Workflows for identifying state-specific cellular changes, trajectories, and evaluating gene regulatory networks. Reproducibility: Fully documented code designed to replicate the primary findings, figures, and computational models presented in the manuscript. Getting Started To get started with the codebase, please refer to the documentation in the README.md file for installation instructions, dependency requirements, and detailed usage guidelines. Citation If you use this software or data in your research, please cite our study: Plasticity of Human Microglia and Brain Perivascular Macrophages in Aging and Alzheimer's Disease. (Full citation/DOI to be updated upon publication).