Life-history trade-off theory has established that humans face competitive energy allocation between cognitive activity and somatic maintenance. However, the central neuroregulatory mechanism governing long-term systemic metabolic strategy remains an unaddressed academic blank. Based on systematic body composition test data of a proband with confirmed temporal lobe positive variant and high sensory processing sensitivity (HSP), this paper proposes an original top-down metabolic suppression hypothesis: individuals with positive temporal lobe variants achieve long-term active downregulation of systemic metabolic rate through the temporal lobe–hypothalamus–autonomic nerve pathway. This neuroregulatory model establishes a stable low-entropy metabolic phenotype characterized by paradoxically low basal metabolism co-occurring with high skeletal muscle ratio, minimal visceral fat, and efficient energy utilization. This study breaks through the existing literature's focus on passive energy trade-offs by proposing an active, brain-initiated metabolic strategy, providing a novel explanatory framework for individual differences in human energy metabolism.