Problem-Based Learning Infographic-Assisted Instruction (PBL-IAI) is an innovative pedagogical approach that combines the depth of inquiry-based learning with the visual clarity of infographics. This study examined the effect of PBL-IAI on the academic performance and scientific attitude of college students enrolled in the GEE1 — Math, Science, and Technology — course during the first semester of the 2025-2026 academic year. The study utilized a quasi-experimental pretest-posttest control group design, involving two sections of second-year BSED students of Roman C. Villalon Memorial Colleges Foundation Inc., who were assigned to the PBL-IAI group (n = 43) and the Non-PBL-IAI group (n = 42), with data gathered through a validated 75-item achievement test and an adapted and modified Scientific Attitude Scale (Khan & Siddiqui, 2020) that also underwent content validation. Students in the PBL-IAI group achieved a post-test Mean Percentage Score of 87.43%, significantly outperforming the Non-PBL-IAI group, which scored 72.16%. Likewise, the PBL-IAI group demonstrated a stronger scientific attitude (M = 3.94) across all four dimensions — rationality, open-mindedness, confidence in the scientific method, and curiosity — than the Non-PBL-IAI group (M = 3.62). The ANCOVA results affirm the synergistic power of combining problem-based learning with infographic-assisted instruction, revealing a significant difference in academic performance and scientific attitude between learners exposed to PBL-IAI and those not exposed to it.