This article presents a comprehensive assessment of the long-term bioecological impacts of atmospheric emissions on urban ecosystems and public health in the industrial regions of Almalyk, Chirchik, and Sergeli. During the study, atmospheric concentrations of PM2.5, PM10, SO₂, NO₂, NH₃, and heavy metal aerosols were monitored. Urban tree species were used as bioindicators to evaluate the ecological condition of the studied areas. GIS-based technologies were applied to develop spatial pollution maps and identify ecological risk zones. The results revealed significant deterioration of air quality in residential areas located near industrial zones. The highest ecological risk was recorded in the Almalyk metallurgical region. The obtained findings contribute to the improvement of bioecological monitoring systems and the development of scientifically grounded strategies aimed at reducing atmospheric emissions in urban-industrial ecosystems.