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Formulation and Evaluation of Effervescent Anti-Diabetic Tablets Using Aegle marmelos Extract for the Management of Type 2 Diabetes Mellitus

Authors: Vaishnavi Tribhuvan*, Gaurav Pawar, Akshada Waghchaure;

Formulation and Evaluation of Effervescent Anti-Diabetic Tablets Using Aegle marmelos Extract for the Management of Type 2 Diabetes Mellitus

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia resulting from impaired insulin secretion, insulin action, or both. Type 2 diabetes mellitus is the most prevalent form and is associated with insulin resistance, obesity, sedentary lifestyle, and genetic predisposition. Conventional anti-diabetic drugs effectively control blood glucose levels but are often associated with adverse effects such as hypoglycemia, gastrointestinal disturbances, and weight gain. Herbal medicines have gained increasing attention as safer alternatives due to their therapeutic efficacy and minimal side effects. Aegle marmelos (Bael or Belpatra), a medicinal plant widely used in Ayurveda, possesses significant anti-diabetic activity owing to the presence of flavonoids, alkaloids, tannins, phenolic compounds, and coumarins. These phytoconstituents exert hypoglycemic effects through stimulation of insulin secretion, inhibition of α-amylase and α-glucosidase enzymes, enhancement of glucose uptake, and reduction of oxidative stress. Effervescent tablets offer advantages such as rapid dissolution, improved bioavailability, enhanced patient compliance, and ease of administration. This review discusses diabetes mellitus, pharmacological properties of Aegle marmelos, formulation strategies for effervescent anti-diabetic tablets, evaluation parameters, and future prospects of herbal effervescent formulations in diabetes management.

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