Alzheimer’s disease (AD) is characterized as a neurodegenerative disorder, commonly seen in elderly people. In India around 3.7 million elderly people are suffering from dementia and it might be raised to increase two-fold by 2030 and threefold by 2050. Recently herbal therapy of Alzheimer’s is gaining the popularity & it allows the researcher to find the better plant-oriented drugs for the treatment of Alzheimer’s disease as current research highlights the usefulness of herbal drugs in management of Alzheimer’s disease. This review collective evidence of Anti-Alzheimer’s potential of medicinal plants. Comprehensive review was done through the data collected through different scientific data bases Pub Med, Science Direct, Google Scholar, SCOPUS & google search engine. The search was done using different key words like Plants, extracts, Alzheimer’s disease, Anti-Alzheimer’s activity, Anti-Alzheimer’s Effect. Result demonstrates extraction was performed using solvents like ethanol, methanol, aqueous, chloroform, n-Hexane. Ethanol was found to be preferred solvent in most of the investigations. Maceration method for the extraction was preferred in extraction. Different in vivo & in vitro methods employed to investigate anti-Alzheimer’s activity of medicinal plants. Possible mechanism of action for the plant is found to inhibit the enzyme cholinesterase, anti-inflammatory action, antioxidant action & affecting Aβ plaques.