Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia resulting from impaired insulin secretion, insulin resistance, or both. The pathophysiology of diabetes involves complex metabolic disturbances that contribute to the development of various complications affecting multiple organs. Increasing evidence suggests that oxidative stress plays a crucial role in the progression of diabetes by promoting the excessive generation of reactive oxygen species, which leads to cellular damage and metabolic dysfunction. In addition, chronic inflammation is considered an important factor in the development of insulin resistance through the activation of inflammatory signaling pathways and the release of pro-inflammatory cytokines. Due to the limitations and side effects associated with conventional antidiabetic drugs, medicinal plants have gained considerable attention as alternative therapeutic o its rich phytochemical composition, including lignans, flavonoids, and phenolic compounds that exhibit strong antioxidant activity. Although direct antidiabetic studies on this plant are limited, its antioxidant potential suggests that it may play a beneficial role in reducing oxidative stress associated with diabetes Therefore, further investigations are required to explore the pharmacological potential. and therapeutic applications of Magnolia liliflora in the management of diabetes.