A Smart Medicine Box is an automated medication- reminder system designed to ensure timely medicine intake, especially for elderly and chronically ill patients. The system integrates an Arduino microcontroller with an RTC module for precise scheduling, a servo motor for compartment control, an LCD for user interface, an LED and buzzer for audiovisual alerts, and an ISD1820 voice playback module amplified by a PAM8403 booster for clear voice reminders. When the preset time arrives, the system alerts the user, opens the correct compartment, and plays a voice message. This work demonstrates an affordable, user-friendly, and reliable solution that improves medication adherence and supports assisted care environments.