Viral Hepatitis A remains a substantial public health challenge worldwide, particularly in densely populated regions such as the Fergana Valley in Uzbekistan. This comprehensive retrospective study aims to analyze the evolving epidemiological trends of Hepatitis A virus infections within the Andijan region over a consecutive three-year period from 2023 to 2025. Leveraging a robust dataset of 6474 laboratory-confirmed cases obtained from the regional sanitary-epidemiological database, the research evaluates shifting transmission dynamics, age-specific vulnerabilities, and seasonal variations. The findings demonstrate a distinct epidemiological transition. The highest incidence rates were overwhelmingly recorded among children aged between three and five years. Furthermore, the analysis reveals that infections are now predominantly sustained within organized collectives, specifically kindergartens and early preschool educational settings. Unlike historical data that characterized Hepatitis A as an infection with pronounced autumn and winter peaks, the current epidemiological picture in Andijan illustrates a persistent, year-round transmission cycle. This shift underscores the critical role of continuous person-to-person spread in crowded pediatric environments rather than purely seasonal or environmental exposures. The study concludes that disrupting this transmission chain requires strategic interventions, including targeted pre-kindergarten vaccination programs and the strict, uninterrupted enforcement of sanitary protocols in educational facilities.