Mast cells can be found in any tissue. The maximum number of them are in dermis, subcutaneous fat, mucous membranes of gastrointestinal tract and respiratory tract. Accordingly, that, mastocytoma may occur anywhere on the body in form of a single node or multiple skin tumors. This tumor develops from mast cells, which contain various inflammatory mediators that can cause edema of surrounding tissues and gastrointestinal syndrome may appear. Signs of systemic lesions include impaired blood coagulation, as well as gastric and duodenal ulcers. Forecast depends on localization of mastocytoma, isolation from the surrounding tissues, tumor growth rate, its size, consistency, differentiate type (determined after a biopsy and cytology). Cytology is a sensitive method of diagnosis “mastocytoma” thanks metachromatic. The need for histological examination mastocytoma — controversial, but allows operedelit degree of differentiation, and hence to establish a more accurate forecast. Mastocytoma is often well demarcated visually, but the absence of the capsule makes adhere to the basic paradigm of surgical treatment of tumors: maximum removal of abnormal tissue, while maintaining the maximum.