Abstract Peptic ulcer sickness and different gastric issues stay fundamental fitness worries global because of growing occurrence related to stress, Helicobacter pylori infection, immoderate alcohol intake, smoking, and extended use of non-steroidal anti-Inflammatory drugs (NSAIDs). Conventional antiulcer cures frequently be afflicted by barriers inclusive of quick gastric house time, terrible bioavailability, common dosing, and systemic facet results. Nanotechnology-primarily based totally drug shipping structures have emerged as promising techniques for enhancing the healing efficacy of Gastroprotective sellers via superior balance, sustained launch, stepped forward mucosal adhesion, and centered drug shipping. Lafutidine, a second-technology histamine H2 receptor antagonist, reveals amazing acid-suppressive and mucosal shielding properties, while Aloin, a herbal anthraquinone glycoside acquired from Aloe species, possesses antioxidant, anti-Inflammatory, cytoprotective, and wound restoration activities. The mixture of those sellers in nanoparticle structures may also offer synergistic gastroprotective results through concurrently decreasing gastric acid secretion and improving mucosal defence mechanisms. This evaluate discusses the formula strategies, coaching methods, characterization parameters, and in vitro assessment of Lafutidine and Aloin-loaded nanoparticles. Different nanoparticle structures which include polymeric, lipid-primarily based totally, and mucoadhesive nanoparticles are reviewed with emphasis on their packages in gastroprotective therapy. The evaluate additionally highlights the significance of physicochemical characterization, drug launch studies, balance assessment, and destiny views of nanoparticle-primarily based totally gastroprotective formulations. Overall, Lafutidine and Aloin-loaded nanoparticles constitute a promising method for enhancing ulcer restoration and improving the effectiveness of gastroprotective therapy. Keywords: Lafutidine, Aloin, nanoparticles, gastroprotective therapy, gastric ulcer, nanotechnology, managed launch, mucoadhesive drug shipping Introduction Peptic ulcer disease (PUD) is characterised via way of means of discontinuation withinside the internal lining of the gastrointestinal (GI) tract due to gastric acid secretion or pepsin. It extends into the muscularis propria layer of the gastric epithelium. It normally happens withinside the belly and proximal duodenum. It can also additionally contain the decrease esophagus, distal duodenum, or jejunum. Epigastric ache normally happens inside 15-half-hour following a meal in sufferers with a gastric ulcer; on the alternative hand, the ache with a duodenal ulcer has a tendency to arise 2-three hours after a meal. Today, trying out for Helicobacter pylori is suggested in all sufferers with peptic ulcer disease. Endoscopy can be required in a few sufferers to affirm the diagnosis, mainly in the ones sufferers with sinister symptoms. Today, maximum sufferers may be controlled with a proton pump inhibitor (PPI) primarily based totally triple-drug therapy (Jaiswal et al., 2021).