Abstract This study aims to analyze the influence of organizational culture and work engagement on employee performance with job satisfaction as an intervening variable at the healthcare service company PT XYZ in the Jember–Banyuwangi area. This research is motivated by the fact that the company's profit targets have not been optimally achieved even though the levels of organizational culture internalization and employee job satisfaction are in the high category. This condition indicates that employee performance is not yet optimal, so an analysis of the factors affecting it is needed. This research uses a quantitative approach with an explanatory research method. The research population is all permanent employees of PT XYZ, totaling 384 people, with a research sample of 372 respondents determined using a purposive sampling technique. Data collection was carried out through the distribution of questionnaires online using Google Form. The data analysis method used is Partial Least Square-based Structural Equation Modeling (SEM-PLS) with the help of SmartPLS 4.0 software. The results of this study indicate that 1) organizational culture has significant effect on employee performance 2) job engagement has significant effect on employee performance 3 organizational culture has significant effect on job satisfaction 4) job engagement has significant effect on job satisfaction 5) job satisfaction has significant effect on employee performance 6) organizational culture has no significant effect on employee performance through job satisfaction 7) job engagement has significant effect on employee performance through job satisfaction