ChatGPT is an artificial intelligence (AI)-based conversational large language model (LLM). The potential applications of LLMs in health care education, research, and practice could be promising if the associated valid concerns are proactively examined and addressed. The current systematic review aimed to investigate the utility of ChatGPT in health care education, research, and practice and to highlight its potential limitations. Using the PRIMSA guidelines, a systematic search was conducted to retrieve English records in PubMed/MEDLINE and Google Scholar (published research or preprints) thaResearch goal: To what extent does EVOR's diverse knowledge base evolution improve LLM performance on out-of-distribution code generation challenges?Autonomous synthesis report generated by SOVEREIGN Research Kernel. Tribunal consensus score: 8.0/10.