Abstract Nanotechnology has emerged as the most promising fields in pharmaceutical and biomedical sciences owing to its wide range of applications in drug delivery, diagnostics, antimicrobial therapy, and tissue engineering. Among various metallic nanoparticles, silver nanoparticles (AgNPs) have gained remarkable attention because of their potent antibacterial, antioxidant, anti-inflammatory, and wound healing properties. Due to its affordability, biocompatibility, and environmental friendliness, green synthesis of silver nanoparticles utilizing extracts from medicinal plants has grown in popularity as an alternative to traditional physical and chemical processes. Campsis grandiflora is a medicinally important plant rich in phytoconstituents such as flavonoids, phenolics, tannins, alkaloids, and terpenoids, which act as natural reducing and stabilizing agents during nanoparticle synthesis. Silver nanoparticles synthesized using Campsis grandiflora extract exhibit enhanced antibacterial activity against several pathogenic microorganisms including Gram-positive and Gram-negative bacteria. This review article discusses the design, green synthesis, preparation methods, physicochemical characterization, and antibacterial evaluation of silver nanoparticles containing Campsis grandiflora extract. The article also highlights the mechanisms of antibacterial action, factors influencing nanoparticle synthesis, and potential pharmaceutical and biomedical of these nanomaterials. The synergistic interaction between silver nanoparticles and plant-derived phytochemicals makes these systems promising candidates for development of advanced antimicrobial formulations. Keywords: Silver nanoparticles, Campsis grandiflora, green synthesis, antibacterial activity, herbal extract, nanotechnology, characterization, phytochemicals.