Clinical pharmacy is an important component of modern healthcare that focuses on the safe, rational, and effective use of medicines to improve patient outcomes. Clinical pharmacists work closely with physicians, nurses, and other healthcare professionals to optimize drug therapy, monitor treatment responses, prevent medication errors, and ensure patient safety. One of the major responsibilities of clinical pharmacy services is the identification, prevention, and management of adverse drug reactions (ADRs). ADRs are defined as unintended and harmful responses to medicines that occur at normal therapeutic doses used for prevention, diagnosis, or treatment of diseases. These reactions may range from mild discomfort to severe life-threatening conditions and can significantly contribute to patient morbidity, mortality, and increased healthcare costs. Monitoring and reporting of ADRs have become an essential part of clinical practice, particularly after historical events such as the Thalidomide disaster, which highlighted the importance of drug safety surveillance. Clinical pharmacists play a vital role in pharmacovigilance activities including detection, documentation, assessment, and reporting of ADRs to national monitoring systems. They utilize various causality assessment tools such as the Naranjo Algorithm and the WHO‑UMC causality assessment system to determine the relationship between the suspected drug and the adverse reaction. In addition to ADR monitoring, clinical pharmacy services include medication reconciliation, therapeutic drug monitoring, patient counseling, participation in ward rounds, and collaboration in multidisciplinary healthcare teams. These services help in reducing medication-related problems, improving therapeutic outcomes, and promoting rational drug use. Furthermore, the integration of pharmacovigilance practices with clinical pharmacy ensures continuous evaluation of drug safety throughout the medication life cycle. Overall, the involvement of clinical pharmacists in ADR detection and pharmacovigilance significantly strengthens patient safety systems within healthcare institutions. Their role in early identification of drug-related problems, risk assessment, and patient education contributes greatly to the prevention of adverse events and enhances the overall quality of healthcare delivery.