Ageing blunts the adaptive growth response in human skeletal muscle. To define the molecular processes underlying this impairment, we performed unbiased analysis of the phosphoproteome and total proteome in healthy young and old human skeletal muscle following acute resistance exercise (ResEX) and essential amino acid (EAA) ingestion. Ageing led to global suppression of the growth-induced global phosphoproteome, despite intact mTORC1 activation in old muscle. Our results identify widespread effects of ageing on skeletal muscle growth and highlight novel pathways for therapeutic developmentin aged skeletal muscle. This repository contains the code and data associated with the paper Ageing blunts the phospho-proteomic response to resistance exercise in humans. https://doi.org/10.64898/2026.06.02.729449 The zip file contains: Processed phosphoproteome and proteome data sets (including missing and imputed values matrices) Differential analysis results. Rokai analysis results. Functional geneset enrichment analysis reactome results. Code for analysis and creating plots and figure panels.