Abstract: Catheter-Associated Urinary Tract Infections (CAUTIs) are among the most common healthcare-associated infections worldwide and significantly contribute to patient morbidity, prolonged hospitalization, increased healthcare costs, and antimicrobial resistance. Nurses play a central role in the prevention of CAUTIs through evidence-based catheter management, infection control practices, patient education, and continuous monitoring. This review article discusses the epidemiology, pathophysiology, risk factors, clinical manifestations, diagnosis, and preventive strategies related to CAUTIs, emphasizing the critical role of nurses in reducing infection incidence. The article also explores nursing interventions, catheter care bundles, aseptic insertion techniques, surveillance systems, patient-centered education, and interdisciplinary collaboration. Strengthening nursing competencies and adherence to evidence-based guidelines are essential for improving patient safety and healthcare quality.