This article analyzes in detail the role, structural components, and significance of the psychological and pedagogical prevention system in preventing drug addiction and substance abuse among youth today. The author scientifically examines the deep socio-psychological factors, personal crises, and risk groups that contribute to the formation of harmful habits in adolescents. Furthermore, practical recommendations are put forward for creating a healthy socio-psychological environment in educational institutions, increasing the socio-psychological immunity of youth against modern synthetic types of substances, and improving the collaborative systemic working methods of educators and psychologists.