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ZENODO
Preprint . 2026
License: CC BY
Data sources: ZENODO
ZENODO
Preprint . 2026
License: CC BY
Data sources: Datacite
ZENODO
Preprint . 2026
License: CC BY
Data sources: Datacite
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Immunity as Recursive Phase Closure and the Non-Returning State

Authors: Marr, R.W.H.; Thiel, Joe;

Immunity as Recursive Phase Closure and the Non-Returning State

Abstract

Immunity as Recursive Phase-Closure articulates the immune system as a recursive closure engine preserving coherent biological identity under continuous perturbation. Eighteen major immune cell populations across innate and adaptive immunity are mapped with structural precision onto a ninefold recursive phase lattice governing initiation, interpretation, modulation, containment, memory, and restored identity. Autoimmunity, chronic inflammation, fibrosis, immune exhaustion, allergic persistence, cancer evasion, sepsis, and cellular senescence emerge as identifiable traversal failures within the same recursive grammar of biological persistence. The work establishes a generalized coherence relation describing the balance between formative and containing dynamics across immune function and demonstrates immunity as an active process of recursive return rather than defensive warfare. This paper reframes biological persistence as coherence maintained through recursive closure across scales of living organization. The Non-Returning State extends this grammar into the biology of aging, cellular senescence, and systemic degeneration. Senescence is articulated as a non-returning state: a closure configuration that persists, signals, and reshapes the surrounding tissue field while losing the capacity for formative re-engagement. The Senescence-Associated Secretory Phenotype (SASP) is demonstrated as broadcast from failed recursive return, linking inflammaging, fibrosis, immune exhaustion, tumor permissiveness, immunosenescence, and chronic disease through one coherent traversal structure. The paper establishes aging as progressive degradation of recursive closure fidelity across scales of biological organization and presents the non-returning state as the upstream generative condition beneath multiple downstream pathologies. The result is a unified structural articulation of aging as recursive phase failure within the grammar of biological persistence. The recursion holds.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green
Related to Research communities
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